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Tiamulin hf

  • Product Name: Tiamulin hf
  • CasNo: 55297-96-6
  • Purity:
  • Appearance: white powder

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CasNo: 55297-96-6

Molecular Formula: C28H47NO4S.C4H4O4

Appearance: white powder

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  • Molecular Formula:C28H47NO4S.C4H4O4
  • Molecular Weight:609.90
  • Appearance/Colour:white powder 
  • Vapor Pressure:5.06E-15mmHg at 25°C 
  • Melting Point:147-148 °C 
  • Boiling Point:563 °C at 760 mmHg 
  • Flash Point:294.3 °C 
  • PSA:166.74000 
  • LogP:4.67970 

Tiamulin fumarate(Cas 55297-96-6) Usage

Indications

Tiamulin fumarate is mainly used for Mycoplasma suis pneumonia, Haemophilus parasuis, infectious pleuropneumonia and dysentery caused by Treponema swine, and also for chronic respiratory tract of poultry, Mycoplasma pneumonia, infectious rhinitis, Escherichia coli, duck Infectious serositis.

Mode of action

Tiamulin fumarate is a bacteriostatic antibiotic belonging to the pleuromutilin class, which inhibit protein synthesis by targeting the 50S bacterial ribosomal subunit and binding to peptidyl transferase, the enzyme responsible for forming peptide bonds between amino acids.

Application

Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity. The hemi-fumarate provides a stable salt with improved water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action of inhibiting protein synthesis by binding to domain V of 23S rRNA.

InChI:InChI=1/C28H47NO4S.C4H4O4/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28;5-3(6)1-2-4(7)8/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t19?,20-,22+,24-,25-,26+,27-,28-;/m0./s1

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