Buy High Quality Quality Factory Supply 4-AminobenzamidineDihydrochloride 2498-50-2 with the Best Price
- Molecular Formula:C7H11Cl2N3
- Molecular Weight:208.09
- Appearance/Colour:white to yellowish fine crystalline powder
- Vapor Pressure:0.00216mmHg at 25°C
- Melting Point:>300 °C(lit.)
- Boiling Point:289.8 °C at 760 mmHg
- Flash Point:129 °C
- PSA：75.89000
- Density:1.26g/cm3
- LogP:3.53810
4-Aminobenzamidine dihydrochloride(Cas 2498-50-2) Usage
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Preparation
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4-Aminobenzamididine dihydrochloride is obtained by cyanation, addition, amination and reduction of 4-nitrobenzoic acid.
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Application
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4-Aminobenzamidine dihydrochloride can be used to synthesize:Orally active fibrinogen receptor antagonists based on benzamidines.Benzamidine derivatives that are selective and potent serine protease inhibitors.Novel pyrrolo [3,2-c] quinolines that are structural analogs of topoisomerase inhibitors such as coralyne and fagaronine.Synthesis of a selective inhibitor of PRMT1 (SKLB-639)
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InChI:InChI=1/C7H9N3/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H3,9,10)/p+1
2498-50-2 Relevant articles
Novel preparation method of p-aminobenzamidine hydrochloride
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Paragraph 0032; 0033; 0035; 0037; 0039; 0041; 0043; 0045, (2018/11/22)
The invention discloses a novel preparat...
Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform
Pant, Shishir M.,Mukonoweshuro, Amanda,Desai, Bimbisar,Ramjee, Manoj K.,Selway, Christopher N.,Tarver, Gary J.,Wright, Adrian G.,Birchall, Kristian,Chapman, Timothy M.,Tervonen, Topi A.,Klefstr?m, Juha
supporting information, p. 4335 - 4347 (2018/05/14)
Hepsin is a membrane-anchored serine pro...
A to prepare to aminobenzoic amidine hydrochloride method
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, (2017/02/02)
The invention relates to the technical f...
Design, synthesis and structure-activity relationships of novel diaryl urea derivatives as potential EGFR inhibitors
Jiang, Nan,Bu, Yanxin,Wang, Yu,Nie, Minhua,Zhang, Dajun,Zhai, Xin
, (2016/12/03)
Two novel series of diaryl urea derivati...
2498-50-2 Process route
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- 25412-75-3
4-nitrobenzamidine
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- 2498-50-2
4-aminobenzamidine dihydrochloride
Conditions
| Conditions |
Yield |
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4-nitrobenzamidine; With iron; acetic acid; In ethanol; water; at 60 - 80 ℃; for 4h;
With hydrogenchloride; In ethanol; water; Reagent/catalyst;
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94.7% |
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- 35704-19-9
N-(4-cyanophenyl)acetamide
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- 2498-50-2
4-aminobenzamidine dihydrochloride
Conditions
| Conditions |
Yield |
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N-(4-cyanophenyl)acetamide; With sodium amide; In dimethyl sulfoxide; at 20 - 80 ℃; for 1.5h; Large scale;
With hydrogenchloride; In ethanol; dimethyl sulfoxide; at 0 ℃; for 1.5h; pH=3 - 4; Solvent; Reagent/catalyst; Temperature; Large scale;
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97.8% |
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