Pharmaceutical intermediates

Home - Products - Pharmaceutical intermediates

4-Cyanopyridine

  • Product Name: 4-Cyanopyridine
  • CasNo: 100-48-1
  • Purity:
  • Appearance: beige solid

Mobile/Wechat/WhatsApp: +86 18892628267

Email:libbywu@fellowchemical.com

Inquiry

CasNo: 100-48-1

Molecular Formula: C6H4N2

Appearance: beige solid

Buy Reliable Quality Quality Factory Supply 4-Cyanopyridine 100-48-1 Customized Supply

  • Molecular Formula:C6H4N2
  • Molecular Weight:104.111
  • Appearance/Colour:beige solid 
  • Vapor Pressure:0.401mmHg at 25°C 
  • Melting Point:76-79 °C(lit.) 
  • Refractive Index:1.539 
  • Boiling Point:196.3 °C at 760 mmHg 
  • PKA:pK1:1.90(+1) (25°C) 
  • Flash Point:82.7 °C 
  • PSA:36.68000 
  • Density:1.12 g/cm3 
  • LogP:0.95328 

4-Cyanopyridine(Cas 100-48-1) Usage

Chemical Description

4-Cyanopyridine and 1,4-dicyanobenzene are organonitriles used in the formation of cationic arene complexes.

Potential Exposure

Limits in Air NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not to be exceeded in any 15-minute work period.

Shipping

UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).

Incompatibilities

Oxidizing agents, such as perchlorates, peroxides, and permanganates. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give car- boxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids .

InChI:InChI=1/C6H4N2/c7-5-6-1-3-8-4-2-6/h1-4H

100-48-1 Relevant articles

An efficient new procedure for the one-pot conversion of aldehydes into the corresponding nitriles

Zhu, Jia-Liang,Lee, Fa-Yen,Wu, Jen-Dar,Kuo, Chun-Wei,Shia, Kak-Shan

, p. 1317 - 1319 (2007)

A new and efficient procedure for the on...

Synthesis of [5-(1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazol-2-yl]pyridines

Pokhodylo,Shiika,Matiichuk,Obushak

, p. 417 - 421 (2010)

2-, 3-, and 4-[5-(1-Aryl-5-R-1H-1,2,3-tr...

Eine effiziente Synthese von 4-Cyanopyridin

Schantl, Joachim,Gstach, Hubert

, p. 694 - 695 (1980)

-

A simple and convenient method for the synthesis of nitriles by oxidation of primary amines with NaOCl in ethanol

Yamazaki, Shigekazu

, p. 3559 - 3564 (1997)

The oxidation of aliphatic primary amine...

An efficient one-pot synthesis of nitriles from carboxylic acids without solvent under microwave irradiation

Juncai, Feng,Bin, Liu,Yang, Lhi,Changchuan, Li

, p. 4545 - 4548 (1996)

Nitriles were prepared from alkyl and ar...

Deoxygenation of pyridine N-oxides with dimethylthiocarbamoyl chloride

Ponaras, Anthony A.,Zaim, Oemer

, p. 487 - 489 (2007)

(Chemical Equation Presented) Treatment ...

A mild deoxygenation of heteroaromatic N-oxides by formamidinesulfinic acid

Balicki, Roman,Chmielowiec, Urszula

, p. 1105 - 1107 (2000)

Various heteroaromatic N-oxides were eff...

Pentacyanoferrates(II): Solvatochromism and Reactivity in Micelles and in Reversed Micelles

Burgess, John,Patei, Marttand S.

, p. 783 - 788 (1993)

Rate constants for dissociation of pyrid...

Efficient and chemoselective deoxygenation of amine N-oxides using polymethylhydrosiloxane

Chandrasekhar,Reddy, Ch. Raji,Rao, R. Jagadeeshwar,Rao, J. Madhusudana

, p. 349 - 351 (2002)

Deoxygenation of aromatic and aliphatic ...

Electronic Effects on the Menschutkin Reaction. A Complete Kinetic and Thermodynamic Dissection of Alkyl Transfer to 3- and 4-Substituted Pyridines

Arnett, Edward M.,Reich, Ronald

, p. 5892 - 5902 (1980)

The relationship between kinetic and the...

Boryl Radicals-Triggered Selective C-H Functionalization for the Synthesis of Diverse Phenanthridine Derivatives

Guo, Ao,Han, Jia-Bin,Tang, Xiang-Ying

, p. 2351 - 2355 (2018)

A boryl radical-triggered C-H functional...

A NEW METHOD FOR DEOXYGENATION OF HETEROAROMATIC N-OXIDES WITH CHLOROTRIMETHYLSILANE/SODIUM IODIDE/ZINC

Morita, Tsuyoshi,Kuroda, Koji,Okamoto, Yoshiki,Sakurai, Hiroshi

, p. 921 - 924 (1981)

Heteroaromatic N-oxides are easily deoxy...

A Novel and Efficient Deoxygenation of Hetero Cyclic N-Oxides Using ZrCl4/NaBH4

Chary, K. Purushothama,Mohan, G. Hari,Iyengar, D. S.

, p. 1339 - 1340 (1999)

A practical and novel reagent system ZrC...

Outer-sphere and inner-sphere processes in organic chemistry. Reaction of trifluoromethyl bromide with electrochemically generated aromatic anion radicals and sulfur dioxide anion radicals

Andrieux,Gelis,Saveant

, p. 786 - 791 (1990)

The reduction of CF3Br by electrochemica...

Highly efficient gold nanoparticle catalyzed deoxygenation of amides, sulfoxides, and pyridine N-oxides

Mikami, Yusuke,Noujima, Akifumi,Mitsudome, Takato,Mizugaki, Tomoo,Jitsukawa, Koichiro,Kaneda, Kiyotomi

, p. 1768 - 1772 (2011)

Selective deoxygenation is one of the mo...

Efficient transformation of aldoximes to nitriles using 2-chloro-1-methylpyridinium iodide under mild conditions

Lee, Kieseung,Han, Sang-Bae,Yoo, Eun-Mi,Chung, Soon-Ryang,Oh, Haibum,Hong, Sungwan

, p. 1775 - 1782 (2004)

Various (aliphatic, aromatic, and hetero...

Efficient catalytic conversion of pyridine N-oxides to pyridine with an oxorhenium(V) catalyst

Wang, Ying,Espenson, James H.

, p. 3525 - 3526 (2000)

(Equation Presented) The compound CH3Re(...

Catalytic deoxygenation of pyridine N-oxides with N-fused porphyrin rhenium complexes

Toganoh, Motoki,Fujino, Keitaro,Ikeda, Shinya,Furuta, Hiroyuki

, p. 1488 - 1491 (2008)

Deoxygenation reactions of pyridine N-ox...

Efficient Deoxygenation of Heteroaromatic N-Oxides with Ammonium Formate as a Catalytic Hydrogen Transfer Agent

Balicki, Roman

, p. 645 - 646 (1989)

Ammonium formate catalytic transfer hydr...

-

Barlin,Brown

, p. 2473 (1967)

-

Catalyst-Free N-Deoxygenation by Photoexcitation of Hantzsch Ester

Cardinale, Luana,Jacobi Von Wangelin, Axel,Konev, Mikhail O.

, (2020)

A mild and operationally simple protocol...

Reaction of N-aminopyridinium salt with cyanide ion.

Okamoto,Hirobe,Tamai

, p. 1089 - 1090 (1963)

-

Facile and Efficient Deoxygenation of Amine-N-oxides with Gallium in Water

Han, Jung Hwa,Choi, Kyung Il,Kim, Joong Hyup,Yoo, Woo Byung

, p. 3197 - 3202 (2004)

A facile and efficient procedure for the...

Reactivity of Heterocyclic Nitrogen Donors in Systems containing the Tetrachloroaurate(III) Anion

Canovese, Luciano,Cattalini, Lucio,Tomaselli, Michele,Tobe, Martin L.

, p. 307 - 314 (1991)

A series of gold(III) complexes of the t...

Chemoselective hydrogenation of nitroarenes and deoxygenation of pyridine N-oxides with H2 catalyzed by MoO2Cl2

Reis, Patrícia M.,Royo, Beatriz

, p. 949 - 952 (2009)

A chemoselective and highly efficient hy...

Formation and Reaction of Trichloro Complexes of Bivalent Transition Metals in 1,2-Dichloroethane

Satoh, Keiichi,Suzuki, Toshio,Sawada, Kiyoshi

, p. 591 - 594 (1988)

Trichloro complexes of some bivalent tra...

Mild and efficient deoxygenation of amine-N-oxides with MoCl5/NaI system

Yoo, Byung Woo,Park, Min Chol

, p. 1646 - 1650 (2008)

The MoCl5/NaI system was found to be a n...

An Efficient Deoxgenation of Heteroaromatic N-Oxides Using Zinc Dust/Ammonium Formate Reagent System

Balicki, Roman,Cybulski, Marcin,Maciejewski, Grzegorz

, p. 4137 - 4141 (2003)

Heteroaromatic N-oxides were readily and...

An overview on the progress and development on the palladium catalyzed direct cyanation

Heydari, Somayyeh,Habibi, Davood,Reza Faraji, Ali,keypour, Hassan,Mahmoudabadi, Masoumeh

, (2021)

Generation of the positive CN ion and th...

Stability studies of bis(pyridiniumaldoxime) reactivators of organophosphate-inhibited acetylcholinesterase

Lin,Klayman

, p. 797 - 799 (1986)

Relative stability studies of three orga...

Facile deoxygenation of amine-N-oxides with CoCl2·6H 2O-indium system

Jung, Hwa Han,Kyung, Il Choi,Joong, Hyup Kim,Cheol, Min Yoon,Byung, Woo Yoo

, p. 415 - 419 (2006)

CoCl2·6H2O/In system was found to be a n...

Selective and efficient deoxygenation of amine-n-oxides with CeCl 3 7H2O/zinc system

Yoo, Byung Woo,Jung, Ha Il,Kim, Se Heon,Ahn, Young Sun,Choi, Ji Yong

, p. 359 - 360 (2013)

-

Interconversion of MeReO(dithiolate)(NC5H4-X) and MeReO(dithiolate)(PAr3) complexes: The equilibrium constants follow the Hammett equation but the rate constants do not

Shan, Xiaopeng,Espenson, James H.

, p. 3612 - 3616 (2003)

Equilibration occurs among the species M...

Efficient Chemoselective Reduction of N-Oxides and Sulfoxides Using a Carbon-Supported Molybdenum-Dioxo Catalyst and Alcohol

Li, Jiaqi,Liu, Shengsi,Lohr, Tracy L.,Marks, Tobin J.

, p. 4139 - 4146 (2019)

The chemoselective reduction of a wide r...

-

Feely,Beavers

, p. 4004,4005 (1959)

-

Mild and efficient method for the synthesis of nitriles

Coskun, Necdet

, p. 1625 - 1630 (2004)

The treatment of aldoximes with a mixtur...

A Versatile VMPO Catalyst Prepared In Situ for Oxidative Ammonolysis of Isomeric Picolines and Xylenes

Dutta, P.,Pathak, D. D.,Senapati, Rabinarayan

, p. 292 - 298 (2020)

Abstract: The V2O5–MoO3–P2O5 (VMPO) cata...

Cyclic Hydroxamic Acid Analogues of Bacterial Siderophores as Iron-Complexing Agents prepared through the Castagnoli–Cushman Reaction of Unprotected Oximes

Bakulina, Olga,Bannykh, Anton,Dar'in, Dmitry,Krasavin, Mikhail

, p. 17667 - 17673 (2017)

The first application of multicomponent ...

Oxidative ammonolysis of 3- and 4-methylpyridines on vanadium oxide catalysts modified with titanium and tin oxides

Mikhailovskaya,Yugay,Chukhno,Sembaev

, p. 191 - 195 (2012)

Catalytic properties of vanadium-titaniu...

Electrochemical Deoxygenation of N-Heteroaromatic N -Oxides

Xu, H.-C.,Xu, P.

, p. 1219 - 1221 (2019)

An electrochemical method for the deoxyg...

Mild Deoxygenation of Sulfoxides over Plasmonic Molybdenum Oxide Hybrid with Dramatic Activity Enhancement under Visible Light

Kuwahara, Yasutaka,Yoshimura, Yukihiro,Haematsu, Kohei,Yamashita, Hiromi

, p. 9203 - 9210 (2018)

Harvesting solar light to boost commerci...

Oxidative ammonolysis of 2,4,6-collidine at vanadium-titanium oxide catalyst

Kagarlitsky,Krichevsky

, p. 315 - 317 (2003)

4-Cyanopyridine was synthesized from the...

A mild and selective deoxygenation of N-oxides with ammonium formate as a catalytic hydrogen transfer agent

Balicki, Roman,Maciejewski, Grzegorz

, p. 1681 - 1683 (2002)

Ammonium formate catalytic transfer hydr...

Photocatalytic deoxygenation of N-O bonds with rhenium complexes: From the reduction of nitrous oxide to pyridineN-oxides

Anthore-Dalion, Lucile,Cantat, Thibault,Kjellberg, Marianne,Nicolas, Emmanuel,Ohleier, Alexia,Thuéry, Pierre

, p. 10266 - 10272 (2021)

The accumulation of nitrogen oxides in t...

-

Afanas'eva et al.

, (1969)

-

-

Prijs et al.

, p. 571,574 (1948)

-

Seeking the Ideal Dehydrating Reagent

Hendrickson, James B.,Hussoin, Md. Sajjat

, p. 4137 - 4139 (1987)

A set of "phosphonium anhydride"reagents...

Oxidative ammonolysis of 3(4)-methyl- and 3,4-dimethylpyridines using vanadium oxide catalysts

Vorobyev,Serebryanskaya

, p. 1987 - 1993 (2012)

Oxidative ammonolysis of 3(4)-methyl- an...

Indium-mediated deoxygenation of amine-N-oxides in aqueous media

Yadav,Subba Reddy,Reddy, M. Muralidhar

, p. 2663 - 2665 (2000)

Several aromatic and aliphatic amine-N-o...

Metal-Free Deoxygenation of Amine N-Oxides: Synthetic and Mechanistic Studies

Lecroq, William,Schleinitz, Jules,Billoue, Mallaury,Perfetto, Anna,Gaumont, Annie-Claude,Lalevée, Jacques,Ciofini, Ilaria,Grimaud, Laurence,Lakhdar, Sami

, p. 1237 - 1242 (2021/06/01)

We report herein an unprecedented combin...

Clean protocol for deoxygenation of epoxides to alkenes: Via catalytic hydrogenation using gold

Fiorio, Jhonatan L.,Rossi, Liane M.

, p. 312 - 318 (2021/01/29)

The epoxidation of olefin as a strategy ...

100-48-1 Process route

4-cyano-1-(4-nitro-phenoxythiocarbonyl)-pyridinium; chloride

4-cyano-1-(4-nitro-phenoxythiocarbonyl)-pyridinium; chloride

pyridine-4-carbonitrile
100-48-1

pyridine-4-carbonitrile

4-nitro-phenol
100-02-7,78813-13-5,89830-32-0

4-nitro-phenol

carbon oxide sulfide
463-58-1

carbon oxide sulfide

Conditions
Conditions Yield
With phosphate buffer; potassium chloride; In water; at 25 ℃; pH=6.5; Further Variations:; pH-values; Kinetics;
 
(E)-4-pyridinecarboxaldehyde O-methyloxime
126527-31-9

(E)-4-pyridinecarboxaldehyde O-methyloxime

pyridine-4-carbonitrile
100-48-1

pyridine-4-carbonitrile

Conditions
Conditions Yield
With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; Ru(CO)(PPh3)3H2; In toluene; for 24h; Heating;
 

100-48-1 Upstream products

  • 123-91-1
    123-91-1

    1,4-dioxane

  • 151-50-8
    151-50-8

    potassium cyanide

  • 22581-65-3
    22581-65-3

    1-Methoxypyridinium iodide

  • 108-89-4
    108-89-4

    picoline

100-48-1 Downstream products

  • 6918-15-6
    6918-15-6

    di-pyridin-4-yl-methanone

  • 56970-92-4
    56970-92-4

    pyridin-2-yl(pyridin-4-yl)methanone

  • 4969-62-4
    4969-62-4

    5-(4’-pyridyl)-3-phenyl-1,2,4-oxadiazole

  • 1122-54-9
    1122-54-9

    methyl (4-pyridyl) ketone

Leave Your Message

Relevant Products