Factory Supply 500011-86-9 with Competitive Price, Buy Reliable Quality 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
- Molecular Formula:C9H5BrClN3O2
- Molecular Weight:302.515
- Vapor Pressure:0Pa at 20℃
- Melting Point:197-200 °C
- Boiling Point:477.4±45.0 °C(Predicted)
- PKA:2.39±0.36(Predicted)
- PSA：68.01000
- Density:1.92±0.1 g/cm3(Predicted)
- LogP:2.38140
500011-86-9 usage
3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid is an organic compound that features a complex structure with multiple functional groups. It contains a pyrazole ring, a five-membered aromatic heterocycle with nitrogen atoms at the 1 and 2 positions, which is substituted with a bromine atom at the 3 position and a carboxylic acid group at the 5 position. Additionally, this pyrazole ring is linked to a 3-chloropyridine moiety, which is a six-membered aromatic ring with nitrogen at the 2 position and a chlorine atom at the 3 position. This compound likely has interesting chemical properties due to the presence of both electron-donating and electron-withdrawing groups, making it potentially useful in various chemical reactions and applications, particularly in the field of medicinal chemistry where such heterocyclic structures are common in bioactive molecules.
500011-86-9 Relevant articles
Design, synthesis and insecticidal-activity evaluation of N-pyridylpyrazolo-5-methyl amines and its derivatives
Yang, Shuai,Xu, Kaijie,Lai, Qiuqin,Zhao, Chen,Xu, Hanhong
, p. 4304 - 4311 (2020)
In searching for novel insecticidal lead...
PROCESS FOR PREPARATION OF SUBSTITUTED PYRAZOLES
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Page/Page column 18-20, (2022/03/09)
: The present invention relates to the p...
METHODS FOR THE PREPARATION OF 5-BROMO-2-(3-CHLORO-PYRIDIN-2-YL)-2H-PYRAZOLE-3-CARBOXYLIC ACID
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Paragraph 0256; 0257, (2021/04/23)
Described herein are novel methods of sy...
METHODS FOR THE PREPARATION OF 5-BROMO-2-(3-CHLORO-PYRIDIN-2-YL)-2H-PYRAZOLE-3-CARBOXYLIC ACID
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Paragraph 0202; 0203, (2021/04/23)
Described herein are novel methods of sy...
METHODS FOR THE PREPARATION OF 5-BROMO-2-(3-CHLORO-PYRIDIN-2-YL)-2H-PYRAZOLE-3-CARBOXYLIC ACID
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Paragraph 0299-0308, (2021/04/23)
Described herein are novel methods of sy...
500011-86-9 Process route
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- 1045077-26-6
3-bromo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-carboxylic acid methyl ester
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- 500011-86-9
3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid
Conditions
| Conditions |
Yield |
|
With sodium hydroxide; In toluene; at 80 - 85 ℃; for 2h;
|
97% |
|
|
|
|
With sodium hydroxide; In water; at 80 ℃; for 2h; Inert atmosphere;
|
|
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With methanol; sodium hydroxide; at 20 ℃; for 1h;
|
|
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With sodium hydroxide; In toluene; at 80 - 85 ℃;
|
|
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With sodium hydroxide; In toluene; at 80 - 85 ℃; for 2h;
|
|
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With sodium hydroxide; In toluene; at 60 ℃; for 3h;
|
16.1 g |
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- 500011-85-8
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine
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- 124-38-9,18923-20-1
carbon dioxide
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- 500011-86-9
3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid
Conditions
| Conditions |
Yield |
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With methylmagnesium bromide; diisopropylamine; In tetrahydrofuran; at 0 ℃; for 2.5h;
carbon dioxide; at 20 ℃; for 1h;
|
95% |
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
carbon dioxide; In tetrahydrofuran; Further stages.;
|
87% |
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
carbon dioxide; In tetrahydrofuran; at -78 - -20 ℃;
|
59% |
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -76 - -71 ℃; for 0.25h;
carbon dioxide; In tetrahydrofuran; at -76 - -57 ℃; for 0.166667h;
|
|
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -76 - -71 ℃; for 0.25h;
carbon dioxide; In tetrahydrofuran; at -57 ℃; for 0.166667h;
With hydrogenchloride; In water;
|
|
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -76 ℃; for 0.25h;
carbon dioxide; In tetrahydrofuran; at -76 - -57 ℃; for 0.166667h;
|
|
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃;
carbon dioxide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - 20 ℃; for 1h;
With water; sodium hydroxide; In tetrahydrofuran; n-heptane; ethylbenzene; at 20 ℃; pH=10 - 12;
|
|
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -76 ℃; for 0.25h;
carbon dioxide; In tetrahydrofuran; at -76 - -57 ℃; for 0.166667h;
|
|
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -76 - -71 ℃; for 0.25h;
carbon dioxide; In tetrahydrofuran; at -76 - -57 ℃; for 0.166667h;
|
27.7 g |
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at 76 ℃; for 0.25h;
carbon dioxide; at 20 - 57 ℃;
|
27.7 g |
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With methylmagnesium chloride; diisopropylamine; In tetrahydrofuran; at 0 ℃; for 2.5h;
carbon dioxide; In tetrahydrofuran; at 20 - 40 ℃;
|
30 g |
|
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine; With methylmagnesium chloride; diisopropylamine; lithium chloride; In tetrahydrofuran; toluene; at 5 - 15 ℃; for 6.75h;
carbon dioxide; In tetrahydrofuran; toluene; for 0.25h; Reagent/catalyst; Temperature; Solvent;
|
46 g |
500011-86-9 Upstream products
-
500011-85-8
2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine
-
124-38-9
carbon dioxide
-
500011-92-7
5-bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid ethyl ester
-
1045077-26-6
3-bromo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-carboxylic acid methyl ester
500011-86-9 Downstream products
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